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Sodium Fluoride

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

2

Screening Libraries

3

Fluorescent Dye

15

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W087383

    Ligands for E3 Ligase Autophagy Apoptosis Cancer
    Thalidomide 5-fluoride is Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
    Thalidomide 5-fluoride
  • HY-W095635

    Biochemical Assay Reagents Others
    Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.
    Tetramethylammonium fluoride tetrahydrate
  • HY-Y0415

    N,N,N-triethylethanaminium (Fluoride)

    Biochemical Assay Reagents Others
    Tetraethylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetraethylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it is used as a catalyst for organic reactions and as a surfactant in the production of semiconductors and microelectronics.
    Tetraethylammonium (fluoride)
  • HY-134983

    E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .
    Thalidomide-Piperazine 5-fluoride
  • HY-W019922

    Biochemical Assay Reagents Others
    Magnesium fluoride is a kind of biological materials or organic compounds that are widely used in life science research .
    Magnesium fluoride
  • HY-W019962

    Biochemical Assay Reagents Others
    Calcium fluoride is a kind of biological materials or organic compounds that are widely used in life science research .
    Calcium fluoride
  • HY-W460193

    Ligands for E3 Ligase Cancer
    N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, used for the synthesis of Anti-inflammatory agent 70 (HY-157570) .
    N-Me-Thalidomide 4-fluoride
  • HY-W145436

    E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis .
    Thalidomide-Piperazine 5-fluoride hydrochloride
  • HY-W093286

    Biochemical Assay Reagents Others
    Aluminum fluoride trihydrate is a kind of biological materials or organic compounds that are widely used in life science research .
    Aluminum fluoride trihydrate
  • HY-W127635

    Biochemical Assay Reagents Others
    Tetraethylammonium fluoride trihydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Tetraethylammonium (fluoride trihydrofluoride)
  • HY-W127636

    Biochemical Assay Reagents Others
    Tetraethylammonium Fluoride Tetrahydrofluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Tetraethylammonium (fluoride tetrahydrofluoride)
  • HY-W075766

    Nickel diFluoride

    Biochemical Assay Reagents Others
    Nickel(II) fluoride (Nickel difluoride) is a fluorinating agent and catalyst suitable for surface treatment of aluminum profiles and the production of inks, fluorescent lamps, and organic synthesis. Nickel(II) fluoride is a kind of biological materials or organic compounds that are widely used in life science research .
    Nickel(II) fluoride
  • HY-W612372

    Fluorosulfonylbenzyl bromide

    Others
    4-(Bromomethyl)benzenesulfonyl fluoride (Fluorosulfonylbenzyl bromide) is an important chemical reagent with good biological activity. 4-(Bromomethyl)benzenesulfonyl fluoride can be used to prepare various bioactive molecules, especially in the process of compound discovery and synthesis, showing excellent reactivity. 4-(Bromomethyl)benzenesulfonyl fluoride is often used in the development of new biological agents, promoting the research progress of organic chemistry and biochemistry.
    4-(Bromomethyl)benzenesulfonyl fluoride
  • HY-Y0971

    TBAF

    Biochemical Assay Reagents Others
    Tetrabutylammonium fluoride is an organic compound containing both ammonium and fluorine functional groups. It is commonly used as a reagent in various chemical synthesis applications, especially as a source of fluoride ions for nucleophilic reactions. Tetrabutylammonium fluoride has several properties that make it suitable for these applications, including its high solubility in polar solvents and its ability to selectively activate certain chemical bonds. In addition, it can be used as a catalyst for organic reactions and as an electrolyte for batteries.
    Tetrabutylammonium (fluoride) (solution),1M in THF
  • HY-41547

    Cereblon ligand 4; E3 ligase Ligand 4

    Ligands for E3 Ligase Autophagy Apoptosis Cancer
    Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966) .
    Thalidomide 4-fluoride
  • HY-164084

    Biochemical Assay Reagents Others
    DBCO-NHCO-C5-O-phenylethenesulfonyl fluoride is a DBCO containing linker, which can be used in bioconjugate, drug delivery and other biochemical research .
    DBCO-NHCO-C5-O-phenylethenesulfonyl fluoride
  • HY-W145623

    2,3,4,6-Tetra-O-benzyl-beta-D-glucopyranosyl Fluoride

    Biochemical Assay Reagents Others
    2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    2,3,4,6-Tetra-O-benzyl-β-D-glucopyranosyl fluoride
  • HY-W145636

    2,3,4,6-Tetra-O-benzyl-alpha-D-glucopyranosyl Fluoride

    Biochemical Assay Reagents Others
    2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl fluoride
  • HY-W145533

    Biochemical Assay Reagents Others
    2,3,4,6-Tetra-O-benzyl-D-glucopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    2,3,4,6-Tetrakis-O-(phenylmethyl)-D-glucopyranosyl fluoride
  • HY-W145569

    (3,4,5-Triacetyloxy-6-fluorooxan-2-yl)methyl acetate

    Biochemical Assay Reagents Others
    2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl Fluoride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    2,3,4,6-Tetra-O-acetyl-D-mannopyranosyl fluoride
  • HY-B0496
    PMSF
    85+ Cited Publications

    Phenylmethylsulfonyl Fluoride; Benzylsulfonyl Fluoride

    Cathepsin Others
    PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates.
    PMSF
  • HY-162704

    PROTACs Cancer
    JMV7048 is an effective PROTAC degrader targeting PXR (Pregnane X Receptor) with a DC50 of 379 nM. JMV7048 induces the polyubiquitination and degradation of PXR protein by recruiting E3 CRBN ubiquitin ligase and the 26S proteasome. JMV7048 significantly enhances the sensitivity of colon cancer stem cells to chemotherapy by reducing the expression of PXR protein in these cells, thereby significantly delaying cancer recurrence in vivo. JMV7048 is composed of the PXR agonist JMV6944 (HY-162738), linker (HY-162736), and Thalidomide 5-fluoride (HY-W087383) (Red: JMV6944; Blue: Thalidomide 5-fluoride ligand; Black: linker) .
    JMV7048
  • HY-169381

    Bcl-2 Family Others
    hMcl-1-IN-1 (Compound 9) is an hMcl-1 inhibitor based on His224 aryl sulfonate fluoride, with an IC50 value of 5.8 nM .
    hMcl-1-IN-1
  • HY-161650

    PROTACs Epigenetic Reader Domain Cancer
    PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 (HY-161651); Black: linker (HY-161653); Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547))
    PROTAC BRD4 Degrader-26
  • HY-D2417

    Fluorescent Dye Others
    SiRA 2 is a near-infrared (NIR) fluoride used in SiRA illumination aptamers. SiRA 2 is capable of imaging single RNA in living cells with maximum excitation emission wavelength: 649/662 nm .
    SiRA 2
  • HY-153220A

    PROTACs Btk Inflammation/Immunology Cancer
    (R)-NX-2127 ((R)-compound 28) is an isomer of the BTK PROTAC degrader NX-2127 (HY-153220) . (R)-NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).
    (R)-NX-2127
  • HY-168190

    PROTACs Cancer
    PROTAC TBL1X degrader-1 (Compound TD11) is a PROTAC degrader for Transducin β-like protein 1 X-linked (TBL1X), and exhibits cytotoxicity in lymphoma cell Riva, Pfeiffer and Granta-519 with IC50 of 0.795, 0.397 and 0.522 μM, respectively. (Pink: ligand for target protein: TBL1X ligand 1 (HY-168191); Black: linker (HY-168193); Blue: ligand for E3 ligase: Thalidomide 4-fluoride (HY-41547))
    PROTAC TBL1X degrader-1
  • HY-W051140

    Disilver sulfate, 99%

    Biochemical Assay Reagents Others
    Silver sulfate, 99% (Disilver sulfate, 99%) can be used for colorimetric determination of nitrates, phosphates, and fluoride, or for the determination of chromium and cobalt in water. Silver sulfate, 99% is a kind of biological materials or organic compounds that are widely used in life science research .
    Silver sulfate, 99%
  • HY-D0133

    Fluorescent Dye Others
    NBD-X acid is a fluorescent probe for the study of fatty acids and sterols. NBD-X acid provides better yields for labelling biopolymers compared to NBD chloride and fluoride. The fluorescence spectrum of the NBD derivative is highly sensitive to the environment and the fluorescence intensity is significantly reduced in aqueous solutions .
    NBD-X acid
  • HY-135859

    ADC Linker Cancer
    NH2-MPAA-NODA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone . NH2-MPAA-NODA can be used as a radiolabel by labeling with 18F-fluoride.
    NH2-MPAA-NODA
  • HY-W036734

    Biochemical Assay Reagents Others
    Tetrabutylammonium (hydrogen difluoride) is a quaternary ammonium salt containing fluoride ions. It is a highly active and effective reagent, often used in organic synthesis reactions, especially for the modification of organic molecules with fluorine atoms. Tetrabutylammonium (hydrogen difluoride) is also used as a catalyst for various chemical reactions such as esterification and transesterification. Additionally, it is used in the production of specialty chemicals such as surfactants and detergents.
    Tetrabutylammonium (hydrogen difluoride)
  • HY-137340

    PROTACs Cancer
    WH-10417-099 is a CRBN-type PROTAC multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). WH-10417-099 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) PI3Kγ ligand 1 (HY-168319), the E3 ubiquitin ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547) and the PROTAC linker (black part) Amino-PEG5-C2-acid (HY-115384). The E3 ligase ligand and linker can form a conjugate Pomalidomide 4'-PEG5-acid (HY-131647).
    WH-10417-099
  • HY-141464

    Fmoc-Asn(Ac3AcNH-beta-Glc)-OH

    Amino Acid Derivatives Cancer
    Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Fmoc-Asn(Ac3AcNH-beta-Glc)-OH) can be used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, as tumor imaging agents, are useful tool for the research of positron emission tomography (PET) .
    Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH
  • HY-161708

    PROTACs CDK FLT3 Cancer
    PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))
    PROTAC FLT3/CDKs degrader-1
  • HY-149917

    PROTACs Itk Cancer
    ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice), with good plasma exposure levels. ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo. ITK degrader 1 consists of target protein ligand (red part) ITK ligand 1 (HY-168387), PROTAC linker (black part) Piperidine-C2-piperazine-Boc (HY-168388) and E3 ubiquitinase ligand (blue part) Thalidomide 5-fluoride (HY-W087383). E3 ubiquitinase and PROTAC linker can form Thalidomide-piperidine-C2-piperazine-Boc (HY-168389) .
    ITK degrader 1
  • HY-153357

    PROTACs Btk Cancer
    NRX-0492 is an orally active PROTAC-class BTK degrader. NRX-0492 catalyzes BTK ubiquitination and proteasome degradation (DC50 ≤ 0.2 nM, DC90 ≤ 0.5 nM) . NRX-0492 inhibits B cell receptor (BCR) mediated signaling, transcription programs, and chemokine secretion. NRX-0492 can bind non-covalently to the BTK binding domain and cereblon, which is an adapter protein in the E3 ubiquitin ligase complex . NRX-0492 consists of a target protein ligand (red part) BTK-IN-40 (HY-170324), an E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383), and a PROTAC linker (black part) (3R)-3-Pyrrolidinemethanol (HY-60263). E3 ubiquitin ligase and linker can form Thalidomide 5-pyrrolidine-CHO (HY-49372A); the active control for the target protein ligand is BTK ligand 12 (HY-49421).
    NRX-0492
  • HY-153220

    PROTACs Btk Cancer
    NX-2127 (compound 28) is an orally active PROTAC deggrader, targeting to Bruton’s Tyrosine Kinase (Btk) . NX-2127 inhibits proliferation of BTK C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells . NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303). Among which, the conjugate of E3 ubiquitin ligase ligand + Linker compose of Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).
    NX-2127
  • HY-164576

    NODA-Bz-SCN

    Radionuclide-Drug Conjugates (RDCs) Cancer
    NCS-MP-NODA (NODA-Bz-SCN) is a bifunctional chelator that can be used to bind to the labeled peptide DK222 with high specificity for PD-L1. The corresponding fluorinated radioactive is synthesized by the aluminum fluoride method, and NCS-MP-NODA targets DK222 to obtain the radioactive analog [18/19F]DK222. [18F]DK222 can quantify PD-L1 in vivo via PET tracking in xenograft models of multiple cancer types.
    NCS-MP-NODA

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